- CAS
- Purity
- 84163-13-3
- 99%
Location：Home > Pharmaceutical
Excellent chemical plant bulk supply 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride 84163-13-3
- Molecular Formula: C12H13FN2O.HCl
- Molecular Weight: 256.707
- Appearance/Colour: white or off-white crystal
- Vapor Pressure: 2.23E-06mmHg at 25°C
- Melting Point: 293-295 °C
- Boiling Point: 387.3 °C at 760 mmHg
- Flash Point: 188 °C
- PSA： 38.06000
- Density: 1.42g/cm3 at 20℃
- LogP: 3.56470
6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride(Cas 84163-13-3) Usage
InChI:InChI=1/C12H13FN2O.ClH/c13-9-1-2-10-11(7-9)16-15-12(10)8-3-5-14-6-4-8;/h1-2,7-8,14H,3-6H2;1H
84163-13-3 Relevant articles
Purification method of 6-fluoro-3-(4-piperidyl)-1,2-benzoisoxazole hydrochloride
-
Paragraph 0029; 0034; 0035, (2021/04/10)
The invention discloses a purification m...
Preparation method of 6-fluoro-3-(4-piperidyl)-1, 2-benzisoxazole hydrochloride
-
Paragraph 0017-0023, (2021/03/05)
The invention provides a preparation met...
Preparation method of risperidone
-
, (2019/04/02)
The invention discloses a preparation me...
Preparation method of iloperidone intermediate
-
Paragraph 0041; 0042, (2017/07/19)
The invention relates to a preparation m...
84163-13-3 Process route
-
-
(2,4-Difluoro-phenyl)-piperidin-4-yl-methanone hydrochloride
-
![6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride](/upload/2026/6/596122d3d3f0419dbf11f186bbc74677_11d3d798-c6af-4984-8ac0-6a8a791b3c68.png)
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84163-13-3
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
Conditions
| Conditions | Yield |
|---|---|
|
(2,4-Difluoro-phenyl)-piperidin-4-yl-methanone hydrochloride;
With
hydroxylamine hydrochloride; potassium hydroxide;
In
methanol;
With
potassium hydroxide;
In
methanol;
at 40 - 45 ℃;
for 12h;
With
hydrogenchloride;
In
methanol; water;
at 0 - 30 ℃;
for 2h;
pH=< 1;
Solvent;
Reagent/catalyst;
Temperature;
Concentration;
|
90.4%
|
|
Multi-step reaction
with
2
steps
1: hydroxylamine hydrochloride; N-methylcyclohexylamine / ethanol / 12 h / 60 °C
2: potassium tert
-butylate; N-methylcyclohexylamine / water; toluene / 6 h / Reflux
With
N-methylcyclohexylamine; hydroxylamine hydrochloride; potassium tert-butylate;
In
ethanol; water; toluene;
|
-
-
84163-46-2
(2,4-difluorophenyl)(4-piperidinyl)methanone oxime
-
-
84163-13-3
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
Conditions
| Conditions | Yield |
|---|---|
|
With
N-methylcyclohexylamine; potassium tert-butylate;
In
water; toluene;
for 6h;
Reflux;
|
97.8%
|
|
(2,4-difluorophenyl)(4-piperidinyl)methanone oxime;
With
potassium hydroxide;
In
water; toluene;
for 6h;
Reflux;
Inert atmosphere;
With
hydrogenchloride;
In
ethanol; water;
at 70 - 80 ℃;
Temperature;
|
96.33%
|
84163-13-3 Upstream products
-
84163-41-7
6-fluoro-3-(1-formyl-4-piperidinyl)-1,2-benzisoxazole
-
84162-94-7
1-formyl-4-(2,4-difluorobenzoyl)piperidine oxime
-
416852-17-0
6-fluoro-3-(1-methylpiperidin-4-yl)benzisoxazole
-
84163-43-9
1-formylisonipecotoyl chloride
84163-13-3 Downstream products
-
84231-26-5
3-{1-[4,4-bis(4-fluorophenyl)-1-butyl]-4-piperidyl}-6-fluoro-1,2-benzisoxazole
-
133454-47-4
iloperidone
-
161884-93-1
(1-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-2-oxo-ethyl}-cyclohexyl)-acetic acid
-
161884-94-2
4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-(5-hydroxy-3,3-pentamethylenepent-1-yl)piperidine