- CAS
- Purity
- 1315478-13-7
- 99%
Location：Home > Pharmaceutical
2-(2-butyl-4-hydroxy-6-MethylpyriMidin-5-yl)-N,N-diMethylacetaMide
2-(2-butyl-4-hydroxy-6-MethylpyriMidin-5-yl)-N,N-diMethylacetaMide 1315478-13-7 with purity >99% Low price in stock
- Molecular Formula: C13H21N3O2
- Molecular Weight: 251.329
- Boiling Point: 385.0±44.0 °C(Predicted)
- PKA: 9.49±0.50(Predicted)
- PSA： 66.32000
- Density: 1.11±0.1 g/cm3(Predicted)
- LogP: 1.46390
1315478-13-7 Relevant articles
Preparation method of N, N-dimethylacetamide
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Paragraph 0051-0052; 0058-0063; 0067-0068; 0097-0098; ..., (2021/09/04)
The invention provides a preparation met...
Method for preparing Fimasartan
-
Paragraph 0043; 0044, (2019/01/16)
The invention discloses a method for pre...
Method for synthesizing Fimasartan
-
Paragraph 0066; 0067; 0068, (2018/05/16)
The invention discloses a method for syn...
A preparation method of the midbody non-Ma Shatan (by machine translation)
-
Paragraph 0048; 0049; 0050; 0051; 0052; 0053; 0054-0057, (2017/06/20)
The invention discloses a method of prep...
1315478-13-7 Process route
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1315478-16-0
2-(2-n-butyl-4-hydroxy-6-methyl-pyrimidin-5-yl)acetic acid
-
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506-59-2
N,N-dimethylammonium chloride
-
-
1315478-13-7
(2-(2-n-butyl-4-hydroxy-6-methyl-pyrimidin-5-yl)-N,N-dimethylacetamide)
Conditions
| Conditions | Yield |
|---|---|
|
2-(2-n-butyl-4-hydroxy-6-methyl-pyrimidin-5-yl)acetic acid;
With
triethylamine;
In
dichloromethane;
at 0 ℃;
for 0.5h;
N,N-dimethylammonium chloride;
With
chloroformic acid ethyl ester;
In
dichloromethane;
for 12h;
Reflux;
With
sodium hydroxide;
In
dichloromethane; water;
pH=9;
|
93%
|
|
With
4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
dichloromethane;
at 0 - 20 ℃;
for 5h;
Inert atmosphere;
|
86%
|
-
-
1315478-14-8
methyl 2-(N,N-dimethylaminocarbonylmethyl)acetoacetate
-
-
18257-46-0
pentanamidine hydrochloride
-
-
1315478-13-7
(2-(2-n-butyl-4-hydroxy-6-methyl-pyrimidin-5-yl)-N,N-dimethylacetamide)
Conditions
| Conditions | Yield |
|---|---|
|
pentanamidine hydrochloride;
With
sodium hydroxide;
In
methanol;
for 0.5h;
Cooling with ice;
methyl 2-(N,N-dimethylaminocarbonylmethyl)acetoacetate;
In
methanol;
at 30 ℃;
for 10h;
Cooling with ice;
|
71.7%
|
|
With
ethanol; potassium hydroxide;
at 25 ℃;
for 15h;
|
70%
|
1315478-13-7 Upstream products
-
1315478-16-0
2-(2-n-butyl-4-hydroxy-6-methyl-pyrimidin-5-yl)acetic acid
-
506-59-2
N,N-dimethylammonium chloride
-
1315478-14-8
methyl 2-(N,N-dimethylaminocarbonylmethyl)acetoacetate
-
18257-46-0
pentanamidine hydrochloride
1315478-13-7 Downstream products
-
247257-48-3
Fimasartan