- CAS
- Purity
- 57470-78-7
- 99%
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Quality products?make an important contribution to long-term revenue and profitability. Factory Sells Best Quality Celiprolol hydrochloride 57470-78-7 with GMP standards
antihypertensive antianginal;beta blocker
celiprolol
(+/-)-celiprolol hydrochloride
| Conditions | Yield |
|---|---|
|
With
hydrogenchloride;
In
acetone;
pH=5.5 - 6;
|
81.3%
|
|
With
hydrogenchloride;
In
acetone;
at 20 ℃;
for 1.5h;
pH=5.5 - 6;
|
80%
|
4-nitrophenol acetate
(+/-)-celiprolol hydrochloride
| Conditions | Yield |
|---|---|
|
Multi-step reaction
with
6
steps
1: aluminum (III) chloride / nitrobenzene / 6.5 h / 20 - 140 °C
2: potassium carbonate; N-benzyl-N,N,N-triethylammonium chloride / 10 h / 75 °C
3: water / 12 h / 20 °C
4: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 1034.32 Torr
5: triethylamine / tetrahydrofuran / 48 h / 40 °C
6: hydrogenchloride / acetone / 1.5 h / 20 °C / pH 5.5 - 6
With
hydrogenchloride; aluminum (III) chloride; palladium 10% on activated carbon; N-benzyl-N,N,N-triethylammonium chloride; hydrogen; potassium carbonate; triethylamine;
In
tetrahydrofuran; methanol; water; nitrobenzene; acetone;
|
|
|
Multi-step reaction
with
6
steps
1: 5% Pd/C; hydrogen / ethyl acetate / 6.5 h / 65 °C / 3750.38 Torr
2: sodium hydrogencarbonate / acetone / 30 °C / Reflux
3: aluminum (III) chloride; sodium chloride / 3 h / 140 °C
4: sodium hydroxide / dimethyl sulfoxide / 12 h / 50 °C
5: ethanol / 8 h / Reflux
6: hydrogenchloride / acetone / pH 5.5 - 6
With
hydrogenchloride; aluminum (III) chloride; 5% Pd/C; hydrogen; sodium hydrogencarbonate; sodium chloride; sodium hydroxide;
In
ethanol; dimethyl sulfoxide; ethyl acetate; acetone;
3: |Fries Phenol Ester Rearrangement / 4: |Williamson Ether Synthesis;
|
The CAS number of Celiprolol hydrochloride is 57470-78-7.
More information of Celiprolol hydrochloride 57470-78-7 are:
|
CAS?Number |
57470-78-7 |
|
Density |
1.114g/cm3 |
|
Melting Point |
197-200 °C (dec.) |
|
Boiling Point |
586.5 °C at 760 mmHg |
|
Flash Point |
308.5 °C |
|
Vapor Pressure |
1.34E-14mmHg at 25°C |
|
PSA |
90.90000 |
|
LogP |
4.15660 |
Synonyms?for?Celiprolol hydrochloride 57470-78-7:Urea,N'-[3-acetyl-4-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]phenyl]-N,N-diethyl-,monohydrochloride (9CI);Celectol;Corliprol;NSC324509;REV 5320A;ST 1396;Selecor;Tenoloc;
The chemical formula of ?Celiprolol hydrochloride is?C20H33N3O4. HCl which containing 20 Carbon atoms,34 Hydrogen atoms,3 Nitrogen atoms,1 Oxygen atoms and 1 Chlorine atoms,and the molecular weight of??Celiprolol hydrochloride?is 415.961.
Celiprolol hydrochloride is a once-daily, cardioselective β-adrenergic blocker useful in the management of hypertension, angina pectoris and hyperkinetic heart syndrome. It is also being evaluated in glaucoma.
InChI:InChI=1/C20H33N3O4.ClH/c1-7-23(8-2)19(26)22-15-9-10-18(17(11-15)14(3)24)27-13-16(25)12-21-20(4,5)6;/h9-11,16,21,25H,7-8,12-13H2,1-6H3,(H,22,26);1H
Relevant articles related to Celiprolol hydrochloride:
|
Article |
Source |
|
A new and improved process for celiprolol hydrochloride |
Joshi, Ramesh A.,Gurjar, Mukund K.,Tripathy, Narendra K.,Chorghade, Mukund S. , p. 176 - 178 (2013/09/07) |
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