- CAS
- Purity
- 7778-42-9
- 99%
Location：Home > Pharmaceutical
Reliable Quality Chlorosulfonamide 7778-42-9 Hot Sale with Chinese Manufacturer
- Molecular Formula: ClH2NO2S
- Molecular Weight: 115.54
- Melting Point: 40-41 °C
- Refractive Index: 1.509
- Boiling Point: 100-105 °C(Press: 4 Torr)
- PKA: 6.82±0.60(Predicted)
- PSA： 68.54000
- Density: 1.788 g/cm3
- LogP: 1.20980
Chlorosulfonamide(Cas 7778-42-9) Usage
InChI:InChI=1/ClH2NO2S/c1-5(2,3)4/h(H2,2,3,4)
7778-42-9 Relevant articles
Carbonic Anhydrase Glycoinhibitors belonging to the Aminoxysulfonamide Series
Ombouma, Joanna,Vullo, Daniella,Dumy, Pascal,Supuran, Claudiu T.,Winum, Jean-Yves
, p. 819 - 821 (2015)
Abstract A general approach for the synt...
Kinetic Resolution of [2.2]Paracyclophane-Derived Cyclic N-Sulfonylimines via Palladium-Catalyzed Addition of Arylboronic Acids
Zhao, Yang,Wang, Xiao-Qing,Yu, Yan-Jiang,Zhou, Yong-Gui
, p. 1262 - 1272 (2021)
A facile method for kinetic resolution o...
Uracil-5-yl O-Sulfamate: An Illusive Radiosensitizer. Pitfalls in Modeling the Radiosensitizing Derivatives of Nucleobases
Arthur-Baidoo, Eugene,Chomicz-Mańka, Lidia,Denifl, Stephan,Falkiewicz, Karina,Kozak, Witold,Makurat, Samanta,Rak, Janusz,Rodrigues Costa, Mateus Salomao,Sikorski, Artur,Spisz, Paulina,Wyrzykowski, Dariusz,Zdrowowicz, Magdalena,Ziegler, Patrick
, p. 5600 - 5613 (2020)
Efficient radiotherapy requires the conc...
Fine-Tuning Strain and Electronic Activation of Strain-Promoted 1,3-Dipolar Cycloadditions with Endocyclic Sulfamates in SNO-OCTs
Burke, Eileen G.,Gold, Brian,Hoang, Trish T.,Raines, Ronald T.,Schomaker, Jennifer M.
, p. 8029 - 8037 (2017)
The ability to achieve predictable contr...
Oxidative Allene Amination for the Synthesis of Azetidin-3-ones
Burke, Eileen G.,Schomaker, Jennifer M.
, p. 12097 - 12101 (2015)
Regioselectivity in the aziridination of...
Rhodium(II)-catalyzed alkyne amination of homopropargylic sulfamate esters: Stereoselective synthesis of functionalized norcaradienes by arene cyclopropanation
Brawn, Ryan A.,Zhu, Kaicheng,Panek, James S.
, p. 74 - 77 (2014)
A rhodium(II) catalyzed nitrene-alkyne c...
Novel steroid sulfatase inhibitors based on N-thiophosphorylated 3-(4-aminophenyl)-coumarin-7-O-sulfamates
Da?ko, Mateusz,Demkowicz, Sebastian,Biernacki, Karol,Harrous, Amira,Rachon, Janusz,Kozak, Witold,Martyna, Aleksandra,Mas?yk, Maciej,Kubiński, Konrad,Boguszewska-Czubara, Anna
, p. 857 - 866 (2019)
In the present work, we described conven...
Stereoselective Synthesis of the β-Amino Acid Moiety of Fijiolide A
Kurzawa, Timon,Kerste, Eric,Nikodemiak, Paul,Bothe, Daniel,Harms, Klaus,Koert, Ulrich
, p. 1261 - 1267 (2019)
An enantioselective synthesis of the β-a...
Synthesis of 7-benzylguanosine cap-analogue conjugates for eIF4E targeted degradation
Kaur, Tanpreet,Menon, Arya,Garner, Amanda L.
, p. 339 - 350 (2019)
Eukaryotic translation initiation factor...
The Influence of the Counterions [AsF6]– and [GeF6]2– on the Structure of the [ClSO2NH3]+ Cation
Leitz, Dominik,Stierstorfer, Karin,Morgenstern, Yvonne,Zischka, Florian,Kornath, Andreas J.
, p. 483 - 488 (2018)
Chlorosulfonamide reacts in the superaci...
Lewis Base-Br?nsted Acid Co-catalyzed Morita-Baylis-Hillman Reaction of Cyclic Sulfamidate Imines
García Manche?o, Olga,Khassenova, Gaukhar
, p. 2752 - 2755 (2021)
A Lewis base-Br?nsted acid co-catalyzed ...
Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors
De Ruysscher, Dries,Pang, Luping,Lenders, Stijn M.G.,Cappoen, Davie,Cos, Paul,Rozenski, Jef,Strelkov, Sergei V.,Weeks, Stephen D.,Van Aerschot, Arthur
, (2020/12/02)
Leucyl-tRNA synthetase (LeuRS) is a clin...
Gold(I)-Catalyzed Intramolecular Dehydrative Amination of Sulfamate Esters Tethered to Allylic Alcohols: A Strategy for the Synthesis of Cyclic Sulfamidates
Park, Yunjeong,Lee, Ji Sun,Ryu, Jae-Sang
supporting information, p. 2183 - 2188 (2021/03/15)
An efficient synthesis protocol for cycl...
7778-42-9 Process route
-
-
1189-71-5
isocyanate de chlorosulfonyle
-
-
7778-42-9
sulphamoyl chloride
Conditions
| Conditions | Yield |
|---|---|
|
With
formic acid;
at 0 - 20 ℃;
for 1h;
|
100%
|
|
With
formic acid;
In
dichloromethane;
at 0 - 20 ℃;
for 12h;
Schlenk technique;
|
97%
|
|
With
formic acid;
at 5 - 40 ℃;
Inert atmosphere;
|
96%
|
|
With
formic acid;
at -15 - 20 ℃;
Inert atmosphere;
|
94.7%
|
|
With
formic acid;
In
toluene;
Cooling with ice;
|
88%
|
|
With
formic acid;
at 0 ℃;
|
86%
|
|
With
formic acid;
In
dichloromethane;
at 0 ℃;
Inert atmosphere;
|
80%
|
|
With
formic acid;
In
dichloromethane;
for 1.75h;
Cooling with ice;
Inert atmosphere;
Reflux;
|
80%
|
|
With
formic acid;
In
toluene;
at 0 ℃;
|
79%
|
|
With
formic acid;
at 4 - 20 ℃;
for 1h;
|
44%
|
|
With
formic acid;
Product distribution / selectivity;
|
|
|
With
formic acid;
at 0 - 20 ℃;
|
|
|
With
water;
In
tetrahydrofuran;
at -20 ℃;
|
|
|
With
water;
In
tetrahydrofuran;
at -20 - 0 ℃;
|
|
|
With
formic acid;
at 0 ℃;
for 0.0833333h;
|
|
|
|
|
|
With
formic acid;
In
toluene;
at 20 ℃;
|
|
|
With
formic acid;
In
acetonitrile;
at 0 - 20 ℃;
for 3h;
|
|
|
With
formic acid;
In
dichloromethane;
for 5h;
Heating / reflux;
|
|
|
With
water;
In
tetrahydrofuran;
at -20 - 0 ℃;
|
|
|
With
water;
In
acetonitrile;
at 0 ℃;
for 1.5h;
|
|
|
With
water;
In
tetrahydrofuran;
at -20 - 0 ℃;
|
|
|
With
formic acid;
at 0 - 20 ℃;
|
|
|
With
formic acid;
at 0 - 20 ℃;
|
|
|
With
formic acid;
at 0 - 20 ℃;
|
|
|
With
formic acid;
at 0 - 20 ℃;
for 3h;
|
|
|
With
water;
In
tetrahydrofuran;
at -20 - 0 ℃;
|
|
|
With
formic acid;
In
acetonitrile;
at 0 - 20 ℃;
|
|
|
With
formic acid;
|
|
|
With
formic acid;
at 0 - 20 ℃;
for 0.25h;
|
|
|
With
formic acid;
In
toluene;
|
|
|
With
formic acid; ISOPROPYLAMIDE;
In
dichloromethane;
at 40 ℃;
|
|
|
With
formic acid;
In
neat (no solvent);
at 0 ℃;
Inert atmosphere;
|
|
|
With
water;
In
tetrahydrofuran;
at 20 ℃;
for 0.5h;
|
|
|
isocyanate de chlorosulfonyle;
With
formic acid;
for 0.166667h;
Inert atmosphere;
Cooling with ice;
In
acetonitrile;
at 20 ℃;
for 1.25h;
|
|
|
With
formic acid;
In
dichloromethane;
at 20 ℃;
for 16.67h;
|
15.8 g
|
|
With
formic acid;
In
acetonitrile;
at 0 - 20 ℃;
for 12h;
|
|
|
With
formic acid;
In
acetonitrile;
at 0 - 20 ℃;
for 8.08h;
|
|
|
With
formic acid;
In
acetonitrile;
at 0 - 20 ℃;
for 2.5h;
Inert atmosphere;
|
|
|
With
formic acid;
In
dichloromethane;
at 0 - 20 ℃;
Inert atmosphere;
Schlenk technique;
|
|
|
With
formic acid;
at -10 ℃;
for 1h;
|
|
|
With
formic acid;
In
dichloromethane;
at 0 - 20 ℃;
for 3h;
Solvent;
|
|
|
With
formic acid;
In
acetonitrile;
at 0 - 25 ℃;
for 8h;
Cooling with ice;
|
|
|
With
formic acid;
at 0 ℃;
|
|
|
With
formic acid;
at 0 - 20 ℃;
|
|
|
With
formic acid;
In
acetonitrile;
at 0 ℃;
for 1.08333h;
|
|
|
With
formic acid; N,N-dimethyl acetamide;
In
dichloromethane;
at 40 ℃;
for 3.5h;
|
|
|
With
formic acid; N,N-dimethyl acetamide;
In
dichloromethane;
at 40 ℃;
for 3.5h;
|
|
|
With
formic acid;
at 20 ℃;
for 1.25h;
Inert atmosphere;
Cooling with ice;
|
|
|
With
formic acid; N,N-dimethyl acetamide;
In
dichloromethane;
at 40 ℃;
for 3.5h;
|
|
|
With
formic acid;
at 0 - 50 ℃;
for 0.166667h;
|
|
|
With
formic acid;
at 0 ℃;
|
|
|
With
formic acid;
In
acetonitrile;
at 0 - 20 ℃;
for 5.08333h;
|
|
|
With
formic acid;
at 20 ℃;
for 0.333333h;
Inert atmosphere;
Cooling with ice;
|
|
|
In
water; acetonitrile;
at 20 ℃;
for 0.25h;
|
|
|
With
formic acid;
at -10 - 20 ℃;
|
|
|
With
formic acid;
In
acetonitrile;
at 0 - 20 ℃;
|
|
|
In
formic acid;
at 0 ℃;
for 1h;
Inert atmosphere;
|
|
|
With
water;
In
tetrahydrofuran;
at -20 - 0 ℃;
|
|
|
With
formic acid;
at 0 ℃;
|
|
|
With
formic acid;
at 25 ℃;
for 1.16667h;
Cooling with ice;
|
|
|
With
formic acid;
In
dichloromethane;
at 0 - 20 ℃;
for 6h;
Heating / reflux;
|
|
|
With
formic acid;
In
dichloromethane;
at 0 - 20 ℃;
for 9h;
Inert atmosphere;
|
|
|
With
formic acid;
In
dichloromethane; N,N-dimethyl acetamide;
at 40 ℃;
for 3.5h;
|
|
|
With
formic acid;
at 0 - 20 ℃;
|
|
|
With
formic acid;
In
dichloromethane;
at 0 - 20 ℃;
for 12h;
|
|
|
With
formic acid;
at 20 ℃;
Inert atmosphere;
|
|
|
With
formic acid;
In
acetonitrile;
at 20 ℃;
for 4h;
|
|
|
With
formic acid;
at 20 ℃;
|
|
|
With
formic acid;
at 20 ℃;
for 0.5h;
Cooling with ice;
Inert atmosphere;
|
|
|
With
formic acid;
at 0 - 20 ℃;
|
|
|
With
formic acid;
at 0 - 25 ℃;
for 1h;
Inert atmosphere;
|
15 g
|
|
With
formic acid;
at 0 - 20 ℃;
|
|
|
With
formic acid; N,N-dimethyl acetamide;
In
dichloromethane;
at 40 ℃;
for 3h;
|
|
|
isocyanate de chlorosulfonyle;
With
formic acid;
at 0 ℃;
for 0.5h;
Inert atmosphere;
In
acetonitrile;
at 20 ℃;
for 5h;
Inert atmosphere;
|
|
|
With
formic acid;
In
neat (no solvent);
at 0 - 20 ℃;
|
|
|
With
formic acid;
at 20 ℃;
for 18h;
Inert atmosphere;
|
|
|
With
formic acid;
at 0 ℃;
|
-
-
64-18-6
formic acid
-
-
1189-71-5
isocyanate de chlorosulfonyle
-
-
7778-42-9
sulphamoyl chloride
Conditions
| Conditions | Yield |
|---|---|
|
In
toluene;
at 23 ℃;
for 10h;
Inert atmosphere;
|
100%
|
|
In
dichloromethane;
at 0 - 22 ℃;
for 12h;
Inert atmosphere;
Schlenk technique;
|
97%
|
|
at 5 - 20 ℃;
|
92%
|
|
In
dichloromethane;
at -78 - 20 ℃;
for 21h;
|
90%
|
|
at 0 - 20 ℃;
Inert atmosphere;
|
80%
|
|
In
benzene;
at 20 ℃;
for 4.5h;
|
40%
|
|
With
triethylamine;
In
dichloromethane;
at 36 - 42 ℃;
Inert atmosphere;
Industry scale;
|
|
|
DMA;
In
dichloromethane;
at 40 ℃;
Product distribution / selectivity;
Reflux;
|
|
|
In
dichloromethane;
at 0 - 20 ℃;
Inert atmosphere;
|
|
|
at 0 - 20 ℃;
for 1h;
|
|
|
In
dichloromethane;
at 0 - 20 ℃;
Inert atmosphere;
|
|
|
With
N,N-dimethyl acetamide;
In
dichloromethane;
|
|
|
In
N,N-dimethyl acetamide;
at 0 - 20 ℃;
for 18h;
|
|
|
at 0 - 20 ℃;
Inert atmosphere;
|
|
|
at 0 ℃;
Inert atmosphere;
Schlenk technique;
|
|
|
In
dichloromethane; N,N-dimethyl acetamide;
at 40 ℃;
for 3.5h;
|
|
|
In
neat (no solvent);
at 0 - 20 ℃;
Inert atmosphere;
Schlenk technique;
|
|
|
at 0 ℃;
|
|
|
In
neat (no solvent);
at 0 - 20 ℃;
|
|
|
In
acetonitrile;
at 20 ℃;
|
7778-42-9 Upstream products
-
1189-71-5
isocyanate de chlorosulfonyle
-
7732-18-5
water
-
64-18-6
formic acid
-
15790-84-8
sodium phenylsulfamate
7778-42-9 Downstream products
-
4403-49-0
ethylsulfamate ester
-
19792-91-7
phenyl sulfamate
-
612531-33-6
N-sulfamoyl-N-phenylglycine ethyl ester
-
1007125-11-2
(1S,2R,3R,5R)-3-{[(aminosulfonyl)oxy]methyl}-5-(isonicotinoylamino)cyclopentane-1,2-diyl dibenzoate