- CAS
- Purity
- 139481-72-4
- 99%
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Candesartan analog as angiotensin II antagonist.
trityl chloride
candesartan
2-Ethoxy-1-[[2'-(N-triphenylmethyltetrazol-5-yl)-biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid
| Conditions | Yield |
|---|---|
|
With
triethylamine;
In
dichloromethane;
at 15 - 23 ℃;
for 3.5h;
Temperature;
Flow reactor;
Large scale;
|
94%
|
|
With
triethylamine;
In
acetone;
at 55 - 60 ℃;
for 4 - 8h;
Product distribution / selectivity;
|
90%
|
|
With
triethylamine;
In
acetone;
at 55 - 60 ℃;
Product distribution / selectivity;
|
90%
|
|
With
triethylamine;
In
methyl iso-butyl ketone (MIBK);
at 55 - 60 ℃;
for 4 - 8h;
Product distribution / selectivity;
|
89%
|
|
With
triethylamine;
In
butanone;
at 55 - 60 ℃;
for 4 - 8h;
Product distribution / selectivity;
|
88%
|
|
With
triethylamine;
In
dichloromethane;
at 25 - 30 ℃;
for 2h;
Heating / reflux;
|
83.8%
|
|
With
triethylamine;
In
dichloromethane;
at 20 ℃;
for 2.5h;
|
53%
|
|
With
triethylamine;
In
dichloromethane;
at 0 - 20 ℃;
for 19h;
|
52.3%
|
|
trityl chloride; candesartan;
With
triethylamine;
In
N,N-dimethyl-formamide;
at 25 - 65 ℃;
With
hydrogenchloride;
In
ethanol; N,N-dimethyl-formamide;
pH=4.6;
|
|
|
With
triethylamine;
In
dichloromethane;
at 0 - 20 ℃;
for 8h;
|
|
|
With
triethylamine;
In
dichloromethane;
at 25 - 35 ℃;
for 3.75h;
|
|
|
With
triethylamine;
In
dichloromethane;
at 0 - 20 ℃;
for 8h;
|
|
|
With
triethylamine;
In
dichloromethane;
at 25 - 35 ℃;
for 20h;
Solvent;
|
125.5 g
|
ethyl acetate-benzene
trityl chloride
candesartan
2-Ethoxy-1-[[2'-(N-triphenylmethyltetrazol-5-yl)-biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid
| Conditions | Yield |
|---|---|
|
With
triethylamine;
In
dichloromethane;
|
66%
|
The CAS number of Trityl candesartan is 139481-72-4.
More information of Trityl candesartan 139481-72-4 are:
|
CAS?Number |
139481-72-4 |
|
Density |
1.26 g/cm3 |
|
Melting Point |
163-165 °C |
|
Boiling Point |
908.6 °C at 760 mmHg |
|
Flash Point |
503.3 °C |
|
Vapor Pressure |
0mmHg at 25°C |
|
Refractive Index |
1.677 |
|
HS CODE |
2933990090 |
|
PSA |
107.95000 |
|
LogP |
8.34220 |
|
Pka |
2.06±0.10(Predicted) |
Synonyms?for?Trityl candesartan 139481-72-4:2-Ethoxy-1-[[2’-(2-Triphenylmethyl)-2H-Tetrazole-5-Yl](1,1’-Biphenyl)-4-Yl]-Methyl]Benzimidazole-7-Carboylicacid;
The chemical formula of ?Trityl candesartan is?C43H34N6O3 which containing 43 Carbon atoms,34 Hydrogen atoms,6 Nitrogen atoms and 3 Oxygen atoms,and the molecular weight of??Trityl candesartan?is 682.781.
Trityl candesartan, also known as 2-Ethoxy-1-((2''-(1-trityl-1H-tetrazol-5-yl)-[1,1''-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylic Acid, is a chemical compound with off-white solid properties. It is a candesartan analog, which is an angiotensin II antagonist, and is primarily used in the preparation of the anti-hypertensive drug candesartan cilexetil.
InChI:InChI=1/C43H34N6O3/c1-2-52-42-44-38-24-14-23-37(41(50)51)39(38)48(42)29-30-25-27-31(28-26-30)35-21-12-13-22-36(35)40-45-46-47-49(40)43(32-15-6-3-7-16-32,33-17-8-4-9-18-33)34-19-10-5-11-20-34/h3-28H,2,29H2,1H3,(H,50,51)
Relevant articles related to Trityl candesartan:
|
Article |
Source |
|
Benzimidazole compound and medical application thereof |
- Paragraph 0038-0041, (2021/05/05) |
|
METHOD FOR PREPARING TRITYL CANDESARTAN |
- Paragraph 0031-0034, (2018/06/15) |
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