- CAS
- Purity
- 125988-01-4
- 99%
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Quality products?make an important contribution to long-term revenue and profitability. Reputable manufacturer supply (5R)-6-Cyano-5-hydroxy-3-oxo-hexanoic Acid tert-Butyl Ester 125988-01-4 in stock with high standard
1.What is the (5R)-6-Cyano-5-hydroxy-3-oxo-hexanoic Acid tert-Butyl Ester ?
Intermediate in the preparation of Atorvastatin 10-Trans (Atorvastatin Impurity AT10)
-
-
540-88-5
acetic acid tert-butyl ester
-
-
141942-85-0
(R)-ethyl 4-cyano-3-hydroxybutyrate
-
-
1694-31-1
tert-butyl acetoacetate
-
-
125988-01-4
tert-butyl (5R)-6-cyano-5-hydroxy-3-carbonylhexanoate
Conditions
| Conditions | Yield |
|---|---|
|
acetic acid tert-butyl ester;
With
ammonia; lithium; isoprene;
In
tert-butyl methyl ether;
at -58 - -48 ℃;
for 5h;
(R)-ethyl 4-cyano-3-hydroxybutyrate;
at -45 - 20 ℃;
|
75 %Chromat.
|
|
acetic acid tert-butyl ester;
With
ammonia; lithium; isoprene;
In
tert-butyl methyl ether;
at -58 - -45 ℃;
for 2.5h;
Inert atmosphere;
Large scale;
(R)-ethyl 4-cyano-3-hydroxybutyrate;
In
tert-butyl methyl ether;
at -46 - -43 ℃;
for 2.5h;
Large scale;
|
75 %Chromat.
|
-
-
540-88-5
acetic acid tert-butyl ester
-
-
141942-85-0
(R)-ethyl 4-cyano-3-hydroxybutyrate
-
-
125988-01-4
tert-butyl (5R)-6-cyano-5-hydroxy-3-carbonylhexanoate
Conditions
| Conditions | Yield |
|---|---|
|
acetic acid tert-butyl ester;
With
lithium diisopropyl amide;
In
tetrahydrofuran;
at -78 ℃;
for 1h;
(R)-ethyl 4-cyano-3-hydroxybutyrate;
In
tetrahydrofuran;
at -40 ℃;
for 4h;
|
99%
|
|
With
lithium diisopropyl amide;
In
tetrahydrofuran;
at -78 ℃;
|
90%
|
|
With
n-butyllithium; diisopropylamine; citric acid;
In
tetrahydrofuran; hexane; toluene;
|
|
|
acetic acid tert-butyl ester;
With
lithium diisopropyl amide;
In
tetrahydrofuran;
at -50 - 25 ℃;
for 1h;
(R)-ethyl 4-cyano-3-hydroxybutyrate;
In
tetrahydrofuran;
at -50 - -25 ℃;
for 2h;
With
hydrogenchloride;
In
tetrahydrofuran; water;
|
|
|
acetic acid tert-butyl ester;
With
lithium diisopropyl amide;
In
tetrahydrofuran;
at -50 - 25 ℃;
for 1h;
(R)-ethyl 4-cyano-3-hydroxybutyrate;
In
tetrahydrofuran;
at -50 - -20 ℃;
for 2h;
With
hydrogenchloride;
In
tetrahydrofuran; water;
|
|
|
acetic acid tert-butyl ester;
With
lithium diisopropyl amide;
In
tetrahydrofuran;
at -50 - 25 ℃;
for 1h;
(R)-ethyl 4-cyano-3-hydroxybutyrate;
In
tetrahydrofuran;
at -50 - -25 ℃;
for 2h;
With
hydrogenchloride; water;
In
tetrahydrofuran;
|
|
|
acetic acid tert-butyl ester;
With
n-butyllithium; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran;
at -50 - 25 ℃;
for 1h;
(R)-ethyl 4-cyano-3-hydroxybutyrate;
In
tetrahydrofuran;
at -50 - -20 ℃;
for 2h;
With
hydrogenchloride;
In
tetrahydrofuran; water;
|
|
|
acetic acid tert-butyl ester;
With
styrene; ammonia; lithium;
In
tert-butyl methyl ether;
at -62 - -46 ℃;
for 0.416667h;
(R)-ethyl 4-cyano-3-hydroxybutyrate;
at -45 - 20 ℃;
Concentration;
Solvent;
|
92 %Chromat.
|
|
acetic acid tert-butyl ester;
With
styrene; ammonia; lithium;
In
tert-butyl methyl ether;
at -62 - -46 ℃;
for 0.416667h;
Inert atmosphere;
(R)-ethyl 4-cyano-3-hydroxybutyrate;
In
tert-butyl methyl ether;
at -46 - -40 ℃;
for 2.5h;
Temperature;
Time;
Thermodynamic data;
|
92 %Chromat.
|
|
acetic acid tert-butyl ester;
With
1,8-diazabicyclo[5.4.0]undec-7-ene;
In
2-methyltetrahydrofuran;
for 5h;
Inert atmosphere;
Reflux;
Green chemistry;
(R)-ethyl 4-cyano-3-hydroxybutyrate;
In
2-methyltetrahydrofuran;
at 20 ℃;
for 1h;
Temperature;
Green chemistry;
|
220 g
|
2.What is the CAS number for (5R)-6-Cyano-5-hydroxy-3-oxo-hexanoic Acid tert-Butyl Ester ?
The CAS number of (5R)-6-Cyano-5-hydroxy-3-oxo-hexanoic Acid tert-Butyl Ester is 125988-01-4.
More information of (5R)-6-Cyano-5-hydroxy-3-oxo-hexanoic Acid tert-Butyl Ester 125988-01-4 are:
|
CAS?Number |
125988-01-4 |
|
Density |
1.125 g/cm3 |
|
Boiling Point |
393.204 °C at 760 mmHg |
|
Flash Point |
191.603 °C |
|
PSA |
87.39000 |
|
LogP |
0.95198 |
|
Pka |
10.31±0.46(Predicted) |
3.What are another words for (5R)-6-Cyano-5-hydroxy-3-oxo-hexanoic Acid tert-Butyl Ester ?
Synonyms?for?(5R)-6-Cyano-5-hydroxy-3-oxo-hexanoic Acid tert-Butyl Ester 125988-01-4:Hexanoic acid, 6-cyano-5-hydroxy-3-oxo-, 1,1-dimethylethyl ester, (R)-;(R)-tert-Butyl 6-cyano-5-hydroxy-3-oxohexanoate;R-tert-Butyl 6-cyano-5-hydroxy-3-oxohexanoate;
4.What is the molecular formula of (5R)-6-Cyano-5-hydroxy-3-oxo-hexanoic Acid tert-Butyl Ester?
The chemical formula of ?(5R)-6-Cyano-5-hydroxy-3-oxo-hexanoic Acid tert-Butyl Ester is?C11H17NO4 which containing 11 Carbon atoms,17 Hydrogen atoms,1 Nitrogen atoms and 4 Oxygen atoms,and the molecular weight of??(5R)-6-Cyano-5-hydroxy-3-oxo-hexanoic Acid tert-Butyl Ester?is 227.26.
5.What is (5R)-6-Cyano-5-hydroxy-3-oxo-hexanoic Acid tert-Butyl Ester (125988-01-4) used for?
(5R)-6-Cyano-5-hydroxy-3-oxo-hexanoic Acid tert-Butyl Ester is an organic compound that serves as an intermediate in the synthesis of Atorvastatin 10-Trans (Atorvastatin Impurity AT10). It is characterized by its yellow oil appearance and possesses a unique molecular structure with a cyano group, hydroxyl group, and an ester functional group.
Relevant articles related to (5R)-6-Cyano-5-hydroxy-3-oxo-hexanoic Acid tert-Butyl Ester:
|
Article |
Source |
|
Preparation method of (R)-6-cyan-5-hydroxy-3-tert-butyl carbonyl hexanoate |
- Paragraph 0022-0023; 0025; 0027, (2018/06/15) |
|
PROCESS FOR CROSSED CLAISEN CONDENSATION REACTIONS PROMOTED BY LITHIUM AMIDE IN LIQUID AMMONIA |
- Page/Page column 9; 10, (2014/02/15) |
6.Buy (5R)-6-Cyano-5-hydroxy-3-oxo-hexanoic Acid tert-Butyl Ester with the best price .
Hangzhou Share Chemical Co., Ltd is a quality supplier of (5R)-6-Cyano-5-hydroxy-3-oxo-hexanoic Acid tert-Butyl Ester. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on (5R)-6-Cyano-5-hydroxy-3-oxo-hexanoic Acid tert-Butyl Ester 125988-01-4.