- CAS
- Purity
- 73874-95-0
- 99%
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Pharma building block.
tert-butyl (1-benzylpiperidin-4-yl)carbamate
(piperidin-4-yl)carbamic acid tert-butyl ester
| Conditions | Yield |
|---|---|
|
With
hydrogen;
palladium 10% on activated carbon;
In
methanol;
for 12h;
|
99%
|
|
With
hydrogen;
palladium 10% on activated carbon;
In
methanol;
for 12h;
|
99%
|
|
With
hydrogen;
palladium on activated charcoal;
In
methanol;
for 18h;
under 2585.74 Torr;
|
97%
|
|
With
hydrogen;
palladium on carbon;
In
methanol;
at 20 ℃;
|
96%
|
|
With
hydrogen;
palladium on activated charcoal;
In
methanol;
at 20 ℃;
|
95%
|
|
With
hydrogenchloride; 10 wt% Pd(OH)2 on carbon; water; hydrogen;
In
methanol;
|
94%
|
|
With
cyclohexene;
palladium dihydroxide;
In
ethanol;
for 3.5h;
Heating;
|
92%
|
|
With
palladium 10% on activated carbon; ammonium formate;
In
methanol;
at 65 ℃;
for 2h;
Reflux;
|
85%
|
|
With
formic acid; potassium hydroxide;
In
ethanol;
at 70 ℃;
for 1h;
|
81%
|
|
With
hydrogen;
palladium 10% on activated carbon;
In
ethanol;
at 20 ℃;
for 16h;
|
76%
|
|
With
hydrogen;
palladium 10% on activated carbon;
In
methanol;
for 18h;
under 2585.81 Torr;
|
|
|
With
hydrogen;
palladium 10% on activated carbon;
In
tetrahydrofuran; ethanol;
|
|
|
palladium-carbon;
In
ethanol;
|
|
|
palladium;
In
ethanol;
|
2.87 g (14.4 mmol, 91.4%)
|
|
palladium;
In
methanol;
|
|
|
palladium on charcoal;
In
methanol;
|
|
|
With
sodium hydroxide; sodium chloride; ammonium formate;
palladium on charcoal;
In
methanol; hexane; water;
|
|
|
With
hydrogen;
palladium 10% on activated carbon;
In
ethanol;
at 20 ℃;
for 24h;
|
|
|
With
hydrogen;
palladium 10% on activated carbon;
In
ethanol;
at 40 ℃;
|
|
|
With
palladium 10% on activated carbon; hydrogen;
In
ethanol;
|
|
|
With
palladium 10% on activated carbon; hydrogen;
In
methanol;
for 24h;
|
|
|
With
acetic acid;
palladium-carbon catalyst;
In
methanol;
|
|
|
With
hydrogen;
palladium 10% on activated carbon;
In
methanol;
for 18h;
under 2585.81 Torr;
|
C17 H24 N2 O2
(piperidin-4-yl)carbamic acid tert-butyl ester
| Conditions | Yield |
|---|---|
|
With
palladium 10% on activated carbon; hydrogen;
In
methanol;
at 70 ℃;
for 4h;
under 6000.6 - 7500.75 Torr;
Reagent/catalyst;
Temperature;
|
90.7%
|
The CAS number of 4-N-Boc-aminopiperidine is 73874-95-0.
More information of 4-N-Boc-aminopiperidine 73874-95-0 are:
|
CAS?Number |
73874-95-0 |
|
Density |
1.02 g/cm3 |
|
Melting Point |
162-166 °C |
|
Boiling Point |
304.8 °C at 760 mmHg |
|
Flash Point |
138.2 °C |
|
Vapor Pressure |
0.000854mmHg at 25°C |
|
HS CODE |
29339900 |
|
PSA |
50.36000 |
|
LogP |
1.98280 |
|
Pka |
12.39±0.20(Predicted) |
Synonyms?for?4-N-Boc-aminopiperidine 73874-95-0:4-N-Boc-amino-piperidine;4-(N-tert-Butoxycarbonylamino)piperidine;4-Boc-AminoPiperidine;4-tert-Butoxycarbonyl-aminopiperidine;4-(N-BOC-amino) piperidine;4-N-Boc-Amino Piperidine;4-(Boc-amino)piperidine;tert-butyl piperidin-4-ylcarbamate;4-(N-Boc-amino)piperidine;4-Boc-amino piperidine;4-Boc-aminopiperindine;4-N-(tert-Butoxycarbonyl)aminopiperidine;N-Boc-piperidin-4-amine;tert-butyl N-(3,4,5,6-tetrahydro-2H-pyridin-4-yl)carbamate;
The chemical formula of ?4-N-Boc-aminopiperidine is?C10H20N2O2 which containing 10 Carbon atoms,20 Hydrogen atoms,2 Nitrogen atoms and 2 Oxygen atoms,and the molecular weight of??4-N-Boc-aminopiperidine?is 236.742.
4-(N-Boc-amino)piperidone may be used as a functionalization reagent for introduction of a primary and a tertiary amino group to poly(2-isopropyl-2-oxazoline. It can also be used as pharma building block. It is used in the synthesis of a piperidine-4-carboxamide CCR5 antagonist with potent anti-HIV 1-activity. It is an intermediate for the synthesis of various pharmaceutical and biologically active compounds, including inhibitors and therapeutic agents. It is used for the synthesis of diphenyl purine derivatives as peripherally selective cannabinoid receptor 1 Antagonists.
InChI:InChI=1/C10H20N2O2/c1-10(2,3)14-9(13)12-8-4-6-11-7-5-8/h8,11H,4-7H2,1-3H3,(H,12,13)/p+1
Relevant articles related to 4-N-Boc-aminopiperidine:
|
Article |
Source |
|
Substituted 2-thioxothiazolidin-4-one derivatives showed protective effects against diabetic cataract via inhibition of aldose reductase |
Huang, Wanrong,Zhang, Yue,Liang, Xu,Yang, Lichun , (2020/04/07) |
|
Method for preparing 4-Boc-aminopiperidine |
- Paragraph 0024; 0026; 0027; 0029; 0030; 0032; 0033; 0035, (2018/04/15) |
Hangzhou Share Chemical Co., Ltd is a quality supplier of 4-N-Boc-aminopiperidine. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on 4-N-Boc-aminopiperidine 73874-95-0.