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7-Troc-paclitaxel

  • CAS
  • Purity
  • 114915-17-2
  • 99%
Inquiry

Good factory supply good 7-Troc-paclitaxel 114915-17-2

  • Molecular Formula: C50H52Cl3NO16
  • Molecular Weight: 1029.32
  • Boiling Point: 1041.1±65.0 °C(Predicted) 
  • PKA: 11.90±0.20(Predicted) 
  • Density: 1.46±0.1 g/cm3(Predicted) 

114915-17-2 Relevant articles

Improved protection and esterification of a precursor of the taxotere and taxol side chains

Commercon,Bezard,Bernard,Bourzat

, p. 5185 - 5188 (2007/10/02)

(4S,5R)-N-BOC-2,2-dimethyl-4-phenyl-5-ox...

Application of the vicinal oxyamination reaction with asymmetric induction to the hemisynthesis of taxol and analogues

Mangatal,Adeline,Guenard,Gueritte-Voegelein,Potier

, p. 4177 - 4190 (2007/10/02)

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114915-17-2 Process route

benzoyl chloride
98-88-4

benzoyl chloride

C<sub>43</sub>H<sub>48</sub>Cl<sub>3</sub>NO<sub>15</sub>
114915-15-0

C43 H48 Cl3 NO15

C<sub>50</sub>H<sub>52</sub>Cl<sub>3</sub>NO<sub>16</sub>
114915-17-2

C50 H52 Cl3 NO16

Conditions
Conditions Yield
With sodium hydrogencarbonate; In water; ethyl acetate;
87%
In pyridine; for 3h; Ambient temperature;
(2R,3S)-3-azido-2-hydroxy-benzenepropanoic acid ethyl ester
144787-20-2

(2R,3S)-3-azido-2-hydroxy-benzenepropanoic acid ethyl ester

C<sub>50</sub>H<sub>52</sub>Cl<sub>3</sub>NO<sub>16</sub>
114915-17-2

C50 H52 Cl3 NO16

Conditions
Conditions Yield
Multi-step reaction with 7 steps
1: 86 percent / H2 / 10percent Pd/C / ethyl acetate / 760 Torr
2: 76 percent / NaHCO3 / CH2 Cl2 / 20 °C
3: 99 percent / pyridinium paratoluenesulfonate (PTSP) / toluene / 80 °C
4: 100 percent / LiOH, H2 O / ethanol / 20 °C
5: 99 percent / DCC, DMAP / toluene / 2 h / 80 °C
6: 80 percent / HCOOH / 4 h / 20 °C
7: 87 percent / NaHCO3 / ethyl acetate; H2 O
With dmap; lithium hydroxide; formic acid; water; hydrogen; pyridinium p-toluenesulfonate; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethanol; dichloromethane; water; ethyl acetate; toluene;

114915-17-2 Upstream products

  • 98-88-4
    98-88-4

    benzoyl chloride

  • 114915-15-0
    114915-15-0

    C43 H48 Cl3 NO15

  • 32981-86-5
    32981-86-5

    10-deacetylbaccatin III

  • 143615-00-3
    143615-00-3

    (2R,3S)-3-amino-3-phenyl-2-hydroxypropionic acid ethyl ester

114915-17-2 Downstream products

  • 33069-62-4
    33069-62-4

    taxol

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