- CAS
- Purity
- 186046-81-1
- 99%
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FMoc-PNA-C(Bhoc)-OH is a peptide nucleic acid (PNA) derivative used in medicinal chemistry and molecular biology. It features a PNA backbone with a fluorenylmethyloxycarbonyl (Fmoc) protecting group at the N-terminus and a 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HBTU) activated carboxylic acid at the C-terminus. The base, N-(9H-fluoren-9-ylmethoxycarbonyl)-N-(2-iodoethoxy-carbonyl)glycine ((9H-fluoren-9-ylmethoxycarbonyl)glycine, abbreviated as Bhoc), is incorporated for stability, making it a versatile compound for the synthesis of PNA and its derivatives.
Used in Pharmaceutical Industry:
FMoc-PNA-C(Bhoc)-OH is used as a building block for the synthesis of peptide nucleic acids and their derivatives. It is utilized for the development of gene therapy, antisense therapy, and diagnostics applications. FMoc-PNA-C(Bhoc)-OH's unique structure allows for the creation of stable and specific PNA molecules that can target and modulate gene expression, offering potential therapeutic benefits in various diseases.
Used in Molecular Biology Research:
In molecular biology, FMoc-PNA-C(Bhoc)-OH serves as a key component in the synthesis of PNA probes and conjugates. These PNA molecules can be used for various research applications, such as DNA and RNA recognition, hybridization studies, and the development of biosensors. FMoc-PNA-C(Bhoc)-OH's versatility and stability make it an essential tool for advancing molecular biology research and understanding the fundamental mechanisms of gene regulation and expression.
Used in Diagnostics:
FMoc-PNA-C(Bhoc)-OH is used as a component in the development of diagnostic tools, such as PNA-based probes for detecting specific nucleic acid sequences. These probes can be employed in various diagnostic assays, including polymerase chain reaction (PCR), fluorescence in situ hybridization (FISH), and microarrays. The high specificity and stability of PNA probes make them valuable for accurate and reliable detection of genetic markers and disease-associated mutations.
The CAS number of FMoc-PNA-C(Bhoc)-OH is 186046-81-1.
More information of FMoc-PNA-C(Bhoc)-OH 186046-81-1 are:
|
CAS?Number |
186046-81-1 |
|
Density |
1.34±0.1 g/cm3(Predicted) |
|
PSA |
169.16000 |
|
LogP |
5.49720 |
|
Pka |
3.14±0.10(Predicted) |
The chemical formula of?FMoc-PNA-C(Bhoc)-OH is C39 H35 N5 O8 which containing 39 Carbon atoms,35 Hydrogen atoms,5 Nitrogen atoms and 8 Oxygen atoms,and the molecular weight, and the molecular weight of FMoc-PNA-C(Bhoc)-OH is 701.736
FMoc-PNA-C(Bhoc)-OH is a peptide nucleic acid (PNA) derivative used in medicinal chemistry and molecular biology. It features a PNA backbone with a fluorenylmethyloxycarbonyl (Fmoc) protecting group at the N-terminus and a 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HBTU) activated carboxylic acid at the C-terminus. The base, N-(9H-fluoren-9-ylmethoxycarbonyl)-N-(2-iodoethoxy-carbonyl)glycine ((9H-fluoren-9-ylmethoxycarbonyl)glycine, abbreviated as Bhoc), is incorporated for stability, making it a versatile compound for the synthesis of PNA and its derivatives.
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